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原标题：短期接触草花粉是否对肺功能和气道炎症有害？
背景：草花粉接触与哮喘恶化的早期标志如肺功能改变和气道炎症增加之间的联系是有限的。我们在一个以群落为基础的样本中调查了短期草花粉接触与肺功能和气道炎症之间的关系，以及这些关系是否受到正在哮喘、花粉热、花粉过敏、年龄和其他环境因素的影响。
方法：数据的横向和短期分析来自于墨尔本特异反应性队列研究（MACS）的参与者（n=936）。肺功能测定采用肺活量法。气道炎症通过呼出气中一氧化氮（FeNO）和呼出冷凝液pH和氮氧化物（NOx）进行评估。每日花粉计数收集使用定容式孢子捕捉器。相关性用线性回归分析。
结果：在较高的环境草花粉水平下接触2天与较低的中期用力呼气流量（FEF25%-75%）和FEV1/FVC比值有关，接触3天的情况也是如此。接触1天高浓度草花粉含量的增加与FeNO（4.35）的增加有关，接触2天的情况也是如此。在哮喘、花粉热和花粉过敏的成人中，花粉接触更会导致多种不良结果。
结论：接触后1-2天，会导致嗜酸性气道炎症，接触后2-3天会引起气道阻塞。患有哮喘、花粉热和花粉过敏的成人可能有更高的风险。


延伸阅读
Allergy                                                   
[IF:6.771]
Is short-term exposure to grass pollen adversely associated with lung function and airway inflammation in the community?
DOI: 10.1111/all.14566
Abstract:
Background: The association between grass pollen exposure and early markers of asthma exacerbations such as lung function changes and increase in airway inflammation is limited. We investigated the associations between short-term grass pollen exposure and lung function and airway inflammation in a community-based sample, and whether any such associations were modified by current asthma, current hay fever, pollen sensitization, age, and other environmental factors.
Methods: Cross-sectional and short-term analyses of data from the Melbourne Atopy Cohort Study (MACS) participants (n = 936). Lung function was assessed using spirometry. Airway inflammation was assessed by fractional exhaled nitric oxide(FeNO) and exhaled breath condensate pH and nitrogen oxides (NOx). Daily pollen counts were collected using a volumetric spore trap. The associations were examined by linear regression.
Results: Higher ambient levels of grass pollen 2 days before (lag 2) were associated with lower mid-forced expiratory flow (FEF25%-75%) and FEV1/FVC ratio (Coef. [95%CI] = −119 [−226, −11] mL/s and −1.0 [−3.0, −0.03] %, respectively) and also 3 days before (lag 3). Increased levels of grass pollen a day before (lag 1) were associated with increased FeNO (4.35 [−0.1, 8.7] ppb) and also at lag 2. Adverse associations between pollen and multiple outcomes were greater in adults with current asthma, hay fever, and pollen sensitization.
Conclusion: Grass pollen exposure was associated with eosinophilic airway inflammation 1-2 days after exposure and airway obstruction 2-3 days after exposure. Adults and individuals with asthma, hay fever, and pollen sensitization may be at higher risk.
First Author:
Nur Sabrina Idrose
Correspondence:
Shyamali Dharmage, Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie St, Carlton, Vic. 3052, Australia.
All Authors:
Nur Sabrina Idrose, Rachel C. A. Tham, Caroline J. Lodge, Adrian J. Lowe, Dinh Bui, Jennifer L. Perret, Don Vicendese, Edward J. Newbigin, Mimi L. K. Tang, Fahad M. Aldakheel, Nilakshi T. Waidyatillake, Jo A. Douglass, Michael J. Abramson, Eugene Haydn Walters, Bircan Erbas, Shyamali C. Dharmage
2021-05-11 Article 
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