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　　原标题：产前颗粒物质通过气道高反应影响学龄儿童新哮喘发生
　　背景：学龄儿童在PM10下暴露影响气道高反应和哮喘新发展的相关时间尚不清楚。本研究的目的是研究PM10暴露对学龄儿童气道高反应最关键的时间和哮喘的新诊断。
　　方法：在2005年至2006之间遴选了3570位学龄儿童，个体每年的PM10暴露量是通过一种普通的克立格方法从产前到7岁估计的。
　　结果： 妊娠期和1岁时PM10暴露对患AHR有显著影响（AOR:1.694，95%CI:1.298-2.209；AOR:1.750，95%CI:1.343-2.282）。妊娠期PM10暴露与新诊断哮喘的风险相关（AOR:2.056，95%CI:1.240-3.409），儿童7岁时患AHR的风险最高（AOR:6.080，95%CI:2.150-17.195）。妊娠中期PM10暴露与7岁AHR儿童患哮喘有最高风险相关（AOR:4.136，95%CI:1.657-10.326）。
　　结论：妊娠中期的产前PM10暴露与7岁学龄儿童哮喘新诊断的风险增加有关。这项研究表明，PM10在子宫内特定三个月的暴露可能通过AHR影响儿童哮喘的发病。


　　延伸阅读
Allergy：
Prenatal particulate matter affects new asthma via airway hyperresponsiveness in schoolchildren
DOI: 10.1111/all.13649
Abstract:
Background: The most relevant time of PM10 exposure to affect airway hyperresponsiveness (AHR) and new development of asthma in school‐aged children is unclear.The aims of this study were to investigate the most critical time of PM10 exposure to affect AHR and new diagnosis of asthma from AHR in school‐aged children.
Methods: Elementary schoolchildren (n = 3570) have been enrolled in a nationwide prospective 4‐year follow‐up survey in Korea from 2005 to 2006. Individual annual PM10 exposure was estimated by using an ordinary kriging method from the prenatal period to 7 years of age. AHR at 7 years was defined by a methacholine PC20≤8 mg/mL.
Results: PM10 exposure during pregnancy and at 1 year of age showed significant effects on AHR (aOR: 1.694, 95% CI: 1.298‐2.209; and aOR: 1.750, 95% CI: 1.343‐2.282, respectively). PM10 exposure during pregnancy was associated with the risk of a new diagnosis of asthma (aOR: 2.056, 95% CI: 1.240‐3.409), with the highest risk in children with AHR at age 7 (aOR: 6.080, 95% CI: 2.150‐17.195). PM10 exposure in the second trimester was associated with the highest risk of a new diagnosis of asthma in children with AHR at age 7 (aOR: 4.136, 95% CI: 1.657‐10.326).
Conclusions: Prenatal PM10 exposure in the second trimester is associated with an increased risk of a new diagnosis of asthma in school‐aged children with AHR at 7 years. This study suggests that PM10 exposure during a specific trimester in utero may affect the onset of childhood asthma via AHR .
First Author:
Song-I Yang
Correspondence:
Soo-Jong Hong, Department of Pediatrics,Childhood Asthma Atopy Center,Environmental Health Center, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
All Authors:
Song-I Yang| So-Yeon Lee | Hyo-Bin Kim | Hwan-Cheol Kim| Jong-Han Leem |Hyeon‐Jong Yang| Hyeok Kwon | Ju-Hee Seo | Hyun-Ju Cho | Jisun Yoon |Eun Lee | Young-Ho Jung | Yeongho Kim | Sungsu Jung | Ho-Jang Kwon |Soo-Jong Hong
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