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原标题：青春期早熟与儿童哮喘风险的孟德尔随机化和纵向研究
背景：有关青春期早期和哮喘发作的研究报告了不一致的结果，并且主要集中在女性上。在这项纵向研究中，我们通过孟德尔随机化（MR）调查了青春期成熟与哮喘之间的因果关系，并探讨了超重和青春期早熟对哮喘的联合影响。
方法：我们使用来自台湾儿童健康研究的数据，对2991名11-17岁儿童进行了纵向随访。六个青春期相关的SNPs（结合成加权等位基因得分）被用来作为青春期早期的遗传工具变量。青春期早熟被定义为某个青春期早于该阶段的中位年龄。通过排除在此年龄之前有哮喘病史的儿童来计算哮喘的发病率。
结果：MR分析的结果表明，青春期早熟与活动性哮喘有关（OR = 1.18； 95％CI：1.08-1.28）； 这种作用在男孩中很明显。青春期早熟显著增加了男女在12和17岁时发生哮喘的风险（危险比= 2.15； 95％CI：1.21-3.84）。 以非超重和非青春期早期儿童为参考组，我们观察到超重和青春期早熟对男女儿童的哮喘风险具有协同作用（OR = 1.08； 95％CI：1.04-1.11）。
结论：建议及早进行肥胖症筛查和干预，以防止将来青春期早期哮喘的发生。


延伸阅读
Allergy                                                
[IF:6.048]
Early pubertal maturation and risk of childhood asthma: A mendelian randomization and longitudinal study
DOI: 10.1111/all.14009
Abstract:
Background: Studies on early puberty and incident asthma have reported inconsistent results and are mainly performed in females. In this longitudinal study, we investigated the causal relationship between pubertal maturation and asthma through Mendelian randomization (MR) and explored the joint effect of overweightness and early pubertal maturation on asthma. 
Methods: We used data from the Taiwan Children Health Study with longitudinal follow‐ups of 2991 children aged 11‐17 years. Six puberty‐related single‐nucleotide polymorphisms (combined into a weighted allelic score) were used to yield genetic instrumental variables for early puberty. Early pubertal maturation was defined as reaching a certain pubertal stage earlier than the median age for that stage. Incident asthma cases were calculated by excluding children with a history of asthma prior to that age.
Results: The results of MR analysis revealed that early pubertal maturation was associated with active asthma (OR = 1.18; 95% CI: 1.08‐1.28); This effect was significant in male children. Early pubertal maturation significantly increased the risk of incident asthma outcomes at 12 and 17 years of age in both sexes (hazard ratio = 2.15; 95% CI: 1.21‐3.84). Taking non‐overweight and non–early puberty children as the reference group, we observed a synergistic effect of overweightness and early pubertal maturation on asthma risk (OR = 1.08; 95% CI: 1.04‐1.11) in children of both sexes.
Conclusion: Early screening and intervention for obesity are recommended to prevent future early pubertal onset and asthma occurrence.
First Author:
Yang‐Ching Chen 
Correspondence:
Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical University, No. 252,Wuxing St, Xinyi District, Taipei 110, Taiwan, China
All Authors:
Yang‐Ching Chen, Hsien‐Yu Fan, Chen Yang, Yungling L. Lee
　　创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。