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　　原标题：出生后18个月鼻腔微生物群的建立:与早期鼻炎和喘息的关系
　　①早期鼻腔微生物群的动态建立影响局部粘膜免疫反应和儿童呼吸道疾病的易感性。②本病例对照研究的目的是监测、评估和比较患有鼻炎和喘息的婴儿在出生后18个月与健康对照组婴儿鼻微生物群的发育情况。③对122名新加坡健康成长(GUSTO)出生队列受试者的前鼻拭子进行了为期18个月的7个时间点的纵向收集。采用16S rRNA多路双端测序法对3组临床患者(1)单纯鼻炎患者(28例)、鼻炎伴喘息患者(34例)和健康对照组(60例)进行鼻微生物区系特征分析。④与对照组相比，两组婴儿鼻炎组的鼻腔微生物群的成熟都遵循独特的模式。对照组患儿18个月期间细菌多样性增加，而鼻炎患儿呈下降趋势(P < 0.05)。增加丰富的Oxalobacteraceae家庭(变形菌门门)和Aerococcaceae家庭(硬壁菌门菌门)与鼻炎和伴随的喘息(P < . 01),而调整棒状杆菌科家族(放线菌门)和早期殖民Staphylococcaceae家庭(厚壁菌门门;与对照组(调整后P < 0.05)比较，差异有统计学意义(P < 0.05)。鼻炎组与对照组的唯一区别是棒状杆菌科的丰度降低(P < 0.05)。决定鼻腔微生物群演替的因素包括性别、分娩方式、是否有兄弟姐妹、是否照顾婴儿。们的研究结果支持了鼻部微生物群参与婴儿早期鼻炎和喘息发展的假说。
延伸阅读
JACI                                                          
[IF:13.1]
Establishment of the nasal microbiota in the first 18 months of life: Correlation with early-onset rhinitis and wheezing
DOI: https://doi.org/10.1016/j.jaci.2018.01.032
 Abstract:
Background
Dynamic establishment of the nasal microbiota in early life influences local mucosal immune responses and susceptibility to childhood respiratory disorders.
Objective
The aim of this case-control study was to monitor, evaluate, and compare development of the nasal microbiota of infants with rhinitis and wheeze in the first 18 months of life with those of healthy control subjects.
Methods
Anterior nasal swabs of 122 subjects belonging to the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) birth cohort were collected longitudinally over 7 time points in the first 18 months of life. Nasal microbiota signatures were analyzed by using 16S rRNA multiplexed pair-end sequencing from 3 clinical groups: (1) patients with rhinitis alone (n = 28), (2) patients with rhinitis with concomitant wheeze (n = 34), and (3) healthy control subjects (n = 60).
Results
Maturation of the nasal microbiome followed distinctive patterns in infants from both rhinitis groups compared with control subjects. Bacterial diversity increased over the period of 18 months of life in control infants, whereas infants with rhinitis showed a decreasing trend (P < .05). An increase in abundance of the Oxalobacteraceae family (Proteobacteria phylum) and Aerococcaceae family (Firmicutes phylum) was associated with rhinitis and concomitant wheeze (adjusted P < .01), whereas the Corynebacteriaceae family (Actinobacteria phylum) and early colonization with the Staphylococcaceae family (Firmicutes phylum; 3 weeks until 9 months) were associated with control subjects (adjusted P < .05). The only difference between the rhinitis and control groups was a reduced abundance of the Corynebacteriaceae family (adjusted P < .05). Determinants of nasal microbiota succession included sex, mode of delivery, presence of siblings, and infant care attendance.
Conclusion
Our results support the hypothesis that the nasal microbiome is involved in development of early-onset rhinitis and wheeze in infants.
All Author:
Le Duc Huy Ta Gaik Chin Yap Carina Jing Xuan Tay Alicia Shi Min Lim Chiung-Hui Huang
Collins Wenhan Chu Paola Florez De Sessions Lynette P. Shek Anne Goh Hugo P.S. Van Bever Oon Hoe Teoh Jian Yi Soh Biju Thomas Mahesh Babu Ramamurthy Daniel Y.T. Goh Christophe Lay Shu-E Soh Yiong Huak Chan Seang-Mei Saw Kenneth Kwek  Yap-Seng Chong Keith M. Godfrey Martin Lloyd Hibberd , Bee Wah Lee xMartin Lloyd HibberdSearch for articles by this author
Affiliations
· Genome Institute of Singapore, Agency for Science, Technology and Research Singapore, Singapore
　　创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。