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原标题：对LTP致敏的桃子过敏患者表型分型及严重程度的生物标志物进行分析
背景：对nsLTP致敏而导致桃子过敏的患者在致敏特性和严重程度方面构成了一个特类。这可能是还存在其他的花粉过敏。本研究旨在分析两个地中海地区不同花粉暴露下的对nsLTP致敏的桃子过敏患者的临床特征、致敏情况和反应的严重程度。
方法：从马拉加地区大学（HRUM）和巴塞罗那医院门诊部（HCB）的过敏科诊断为LTP过敏的患者分为两组：（a）单LTP过敏组：仅对桃子有反应的患者；和（b）多LTP过敏组：与桃子和至少另一种含有LTP的植物性食物发生反应。
结果：252例患者中，235例（93.2%）为LTP综合征，17例（6.8%）为LTP无反应性。我们发现在单LTP过敏组中，过敏反应的百分比较高且症状发作延迟（分别为p=0.02和p=0.04）。此外，profilin致敏患者过敏反应发生率较低（p=0.03）。HRUM与HCB数据比较显示，患者对橄榄树花粉和profilin的致敏性存在差异（分别为p=0.01和p=0.001）
结论：本研究发现两个人群中超过90%的桃子过敏患者会演变为LTP过敏并表现出早期发作。作为严重程度的生物标志物，Profilin的致敏性可能比nsLTP和吸入性过敏原的致敏性或sIgE水平更有用。本研究可能为其他地区相关的致敏性和严重程度模式提供线索。


延伸阅读
Allergy                                                    
Phenotyping peach-allergic patients sensitised to LTP and analysing severity biomarkers
DOI: 10.1111/ALL.14447
Abstract:
Background: Patients with peach allergy due to nsLTP sensitisation constitute a heterogeneous group in terms of sensitisation profile and severity. This could be due to the presence of additional allergies to pollens. The aim of this study was to analyse the clinical characteristics, sensitization profile, and severity of reactions in peach-allergic patients sensitised to nsLTP from two Mediterranean areas with different pollen exposure.
Methods: Patients with diagnosis of LTP allergy from the Allergy Unit of Hospital Regional Universitario de Malaga (HRUM) and Hospital Clinic de Barcelona (HCB) were prospectively included and classified into two groups; (a) LTP-monoallergic: those that presented reaction only with peach, and (b) LTP-Allergy: those that presented reaction with peach and at least another plant-food containing LTP.
Results: 252 patients were included, 235 (93.2%) had LTP-syndrome and 17 (6.8%) were LTPmonoallergic. We found a higher percentage of anaphylaxis and delayed onset of symptoms in the LTP-monoallergic group (p=0.02 and p=0.04, respectively). Moreover, anaphylaxis was less frequent in patients with profilin sensitisation (p=0.03). The comparison of patients’ data from HRUM with data from HCB showed differences in sensitisation to olive tree pollen and profilin (p=0.01 and p=0.001, respectively).
Conclusion: This study was undertaken to characterize two large group of subjects from to two regions with differing exposures to pollen. We found that more than 90% of peach-allergic patients in both populations evolved to LTP-Allergy and showed an early onset. Profilin sensitisation could be more useful as a severity biomarker than the number of nsLTP, aeroallergen sensitisations, or sIgE levels. This could provide clues regarding sensitisation and severity patterns that might be relevant in other geographical areas.
First Author:
Bogas G  
Correspondence:
Allergy Service of the Hospital Regional Universitario de Málaga IBIMA- Hospital Regional Universitario de Málaga (Pavillion C). Plaza del Hospital Civil. 29009 Málaga, Spain
All Authors:
Bogas G, Muñoz-Cano R, Mayorga C, Casas R, Bartra J, Pérez N, Pascal M , Palomares F, Torres MJ, Gómez F
2020-12-18 Article 
　　创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。