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　　原标题：IgE对Bet v 1同源物和抑制蛋白（profilin）无反应的水果过敏患者中赤霉素调节蛋白(peamaclein)的致敏率高：赤霉素调节蛋白过敏的临床模式、致敏水果和辅助因素
　　①赤霉素调节蛋白(GRP)是一种新发现的桃子过敏原，其氨基酸序列在多种植物中均有很好的保存。我们研究了GRP在桃子以外的水果过敏中的致敏性，并确定了GRP致敏的水果过敏患者的临床特征。本研究以日本100例连续水果过敏患者为研究对象。为了确定GRP致敏的特征，我们选择了Bet v1同源物和抑制蛋白（profilin）ImmunoCAP结果为阴性的患者，这两者是花粉-食物过敏综合征(PFAS) 的标记过敏原或脂质转移蛋白。用纯化的nPru p7通过酶联免疫吸附试验(ELISA)对这些患者进行特异性IgE检测和皮肤点刺试验(SPT)。在100名连续水果过敏患者中，有20名患者的Bet v1同源物和profilinImmunoCAP检测结果呈阴性。20例患者中13例(65.0%)ELISA和/或SPT结果为阳性，而20例患者中有1例Pru p3ImmunoCAP结果为阳性。在13例nPru p7敏感患者中，致敏食物为桃子(92.3%)、杏(61.5%)、桔子(46.2%)和苹果(30.8%)。10例(76.9%)有多种致果性。常见的症状包括面部水肿(92.3%)和喉部紧张(66.7%)。在8例(61.5%)患者中，运动或服用阿司匹林作为辅助因素可增强过敏反应的发生。除PFAS外，日本水果过敏患者GRP致敏率较高。总之，GRP敏感患者可能对多种水果过敏，并可能表现出特殊的特征，如面部肿胀和辅助因素依赖性。
延伸阅读
JAD                                                    
High prevalence of sensitization to gibberellin‐regulated protein (peamaclein) in fruit allergies with negative immunoglobulin E reactivity to Bet v 1 homologs and profilin: Clinical pattern, causative fruits and cofactor effect of gibberellin‐regulated protein allergy
https://doi.org/10.1111/1346-8138.13795
Gibberellin‐regulated protein (GRP) is a new allergen in peach allergy, with an amino acid sequence very well conserved through several botanical species. We investigated the allergenicity of GRP in fruit allergies other than peaches and identified the clinical characteristics of fruit allergy patients with GRP sensitization. One hundred consecutive Japanese patients with fruit allergies were enrolled in the present study. To identify the features of GRP sensitization, we selected patients with negative ImmunoCAP results for Bet v 1 homologs and profilin, which are marker allergens for pollen‐food allergy syndrome (PFAS), or lipid transfer protein. These patients underwent specific immunoglobulin E measurements by enzyme‐linked immunosorbent assay (ELISA) and skin prick tests (SPT) using purified nPru p 7. Twenty of 100 consecutive patients with fruit allergies had negative ImmunoCAP results for Bet v 1 homologs and profilin. Thirteen (65.0%) of the 20 patients had positive ELISA and/or SPT results using nPru p 7, whereas one of the 20 patients had positive ImmunoCAP results for Pru p 3. In 13 nPru p 7‐sensitized patients, the causative foods were peaches (92.3%), apricots (61.5%), oranges (46.2%) and apples (30.8%). Ten patients (76.9%) had multiple causative fruits. Frequent symptoms included facial edema (92.3%) and laryngeal tightness (66.7%). In eight patients (61.5%), exercise or aspirin intake enhanced the allergic reaction onset as cofactors. The prevalence of GRP sensitization was high in Japanese fruit allergy patients except for PFAS patients. In conclusion, GRP‐sensitized patients may have allergies to multiple fruits and may show peculiar characteristics such as facial swelling and cofactor dependence.
All Author:
Naoko Inomata, M.D., Ph.D  Mami Miyakawa  Michiko Aihara
　　创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。